Clinical Evidence & Research

Dry Eye & Ocular Surface Disease

 

IPL & RF 

 

Dell et al. 2017

In a prospective clinical study, IPL treatment improved meibomian gland function, tear stability, and dry eye symptoms in patients with evaporative dry eye.

https://pdfs.semanticscholar.org/063b/ec4dc979ecd382a7a3ad314670dd383d1923.pdf

 

Martínez-Hergueta et al., Asia-Pacific Journal of Ophthalmology, 2023 (IPL perioperative RCT)

In a randomized, triple-masked clinical trial, perioperative IPL therapy significantly improved tear stability, meibomian gland function, and dry eye symptoms after laser refractive surgery compared to controls.

https://miamieyedoctor.com/wp-content/uploads/2026/04/2023-Alioe-et-al-IPL-perioperative-LASIK-SMILE.pdf

 

Chelnis et al., Clinical Ophthalmology, 2023 (IPL + RF combination study)

In a prospective clinical study, combination therapy with IPL, radiofrequency, and meibomian gland expression significantly improved meibomian gland function and dry eye symptoms, with greater improvement compared to IPL alone.

https://miamieyedoctor.com/wp-content/uploads/2026/04/Multi-Frequency-RF-Combined-with-Intense-Pulsed-Light-Improves-Signs-and-Symptoms-of-Dry-Eye-Disease-Due-to-Meibomian-Gland-Dysfunction.pdf

 

Prokera Amniotic Membrane 

Cheng et al. Prokera Dry Eye Study

In a prospective clinical study, cryopreserved amniotic membrane (Prokera®) significantly improved signs and symptoms of moderate to severe dry eye disease, promoting rapid ocular surface healing and reducing inflammation.

https://pubmed.ncbi.nlm.nih.gov/26387870/

 

Myopia Control

Stellest Lens

Bao et al. 2022 Stellest HALT Study

In a 2-year randomized clinical trial of 157 children, spectacle lenses with aspherical lenslets significantly slowed myopia progression and axial elongation compared to single-vision lenses, with greater efficacy seen in higher asphericity designs.

https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2790589

 

Ortho-Keratology

Cho et al. 2012 ROMIO Study

In a 2-year randomized clinical trial, orthokeratology lenses slowed axial elongation by approximately 43% compared to single-vision spectacles in myopic children.

https://pubmed.ncbi.nlm.nih.gov/22969068/

 

MiSight Contact Lenses

Chamberlain et al. 2019 – A 3-year Randomized Clinical Trial of MiSight Lenses for Myopia Control

In a 3-year double-masked, multicenter randomized clinical trial, MiSight® 1-day lenses reduced myopia progression by ~59% and axial elongation by ~52% compared to single-vision lenses in children.”

https://pubmed.ncbi.nlm.nih.gov/31343513/

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